Journal Reviews

Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

1 October 2016 | | Retina / Uvea / Vitreous | chemotherapy, intra-ocular tumour, retinal pigment epithelium, retinoblastoma, toxicity

There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Air toxicity on retinal pigment epithelium

1 August 2015 | | Retina / Uvea / Vitreous | Air toxicity, internal gas tamponade, pars plana vitrectomy, pneumoretinopexy, retinal pigment epithelium

This study investigated the potential toxic effects of air on primary human retinal pigment epithelial (RPE) cells in vitro. Clinically during pars plana vitrectomy air is used as either a temporary tamponade during air-fluid exchange or mixed with gas to...